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Co-culture of <t>MCL</t> cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived <t>from</t> <t>lymphoma</t> and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.
Human Mantle Cell Lymphoma Mcl Cell Lines Mino, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Co-culture of <t>MCL</t> cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived <t>from</t> <t>lymphoma</t> and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.
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Co-culture of <t>MCL</t> cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived <t>from</t> <t>lymphoma</t> and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.
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Co-culture of <t>MCL</t> cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived <t>from</t> <t>lymphoma</t> and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.
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ATCC human mantle cell lymphoma mcl jeko 1 cells
Co-culture of <t>MCL</t> cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived <t>from</t> <t>lymphoma</t> and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.
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Co-culture of MCL cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived from lymphoma and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.

Journal: Journal of Advanced Research

Article Title: Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance

doi: 10.1016/j.jare.2024.08.023

Figure Lengend Snippet: Co-culture of MCL cells with macrophages. (A-B) The M2-to-M1 ratio of macrophages from both ibrutinib-sensitive and −resistant subjects was analyzed using macrophage samples derived from lymphoma and blood. (C) Enrichment analysis of the KEGG signaling pathways conducted using the “clusterProfiler” package revealed significantly enriched KEGG pathways associated with correlated protein-coding genes. (D) A schematic diagram of the co-culture system illustrates MCL cells located on the upper side and macrophages on the lower side, separated by polycarbonate pore membranes with a pore size of 0.4 μm. (E) Mino and JEKO-1 cells were treated with the indicated concentrations of ibrutinib, with or without macrophages. Cell viability was evaluated using the CCK-8 assay, and control cells were treated with DMSO. (F-G) Cell apoptosis ratios were analyzed by flow cytometry. Mino and JEKO-1 cells were treated with either DMSO or 1 μM ibrutinib, and the percentages of Annexin V/PI (propidium iodide)-positive cells were measured. ****p < 0.0001.

Article Snippet: Human mantle cell lymphoma (MCL) cell lines Mino and JEKO-1 were obtained from the American Type Culture Collection (ATCC, Manassas, Virginia, USA).

Techniques: Co-Culture Assay, Derivative Assay, Protein-Protein interactions, Pore Size, CCK-8 Assay, Control, Flow Cytometry

Combination of CXCR2 inhibitor and ibrutinib displayed high synergistic inhibition of MCL growth. (A, B) The apoptosis of ibrutinib-treated cells was assessed using flow cytometry following treatment with CXCL5 or co-culture conditions. (C) Caspase-3 activity in Mino and JEKO-1 cells was measured under CXCL5 or co-culture treatments. (D) Compusyn software was employed to analyze the inhibition rates of malignant cells (MCLs) under ibrutinib, SB225002, and the combination of ibrutinib and SB225002 in a co-culture system. (E) The combined drug index (CI) of ibrutinib combined with SB225002 was analyzed using Compusyn software at different inhibition rates. (F) The dose-reduction index (DRI) of ibrutinib and SB225002 is presented. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Fa: Fraction affected.

Journal: Journal of Advanced Research

Article Title: Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance

doi: 10.1016/j.jare.2024.08.023

Figure Lengend Snippet: Combination of CXCR2 inhibitor and ibrutinib displayed high synergistic inhibition of MCL growth. (A, B) The apoptosis of ibrutinib-treated cells was assessed using flow cytometry following treatment with CXCL5 or co-culture conditions. (C) Caspase-3 activity in Mino and JEKO-1 cells was measured under CXCL5 or co-culture treatments. (D) Compusyn software was employed to analyze the inhibition rates of malignant cells (MCLs) under ibrutinib, SB225002, and the combination of ibrutinib and SB225002 in a co-culture system. (E) The combined drug index (CI) of ibrutinib combined with SB225002 was analyzed using Compusyn software at different inhibition rates. (F) The dose-reduction index (DRI) of ibrutinib and SB225002 is presented. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Fa: Fraction affected.

Article Snippet: Human mantle cell lymphoma (MCL) cell lines Mino and JEKO-1 were obtained from the American Type Culture Collection (ATCC, Manassas, Virginia, USA).

Techniques: Inhibition, Flow Cytometry, Co-Culture Assay, Activity Assay, Software